By Dr. Gernot Stuhler, Prof. Dr. Peter Walden
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Cerottini, J. C. and Cerundolo,V. Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen-experienced tumor-specific cytolytic T lymphocytes, J Exp Med 188: 1641±50, 1998. 28 Vonderheide, R. , Hahn,W. , Schultze, J. L. and Nadler, L. M. The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes, Immunity 10: 673±9, 1999. 29 Kim, N. , Piatyszek, M. , Prowse, K. , Harley, C.
Epitope deduction has been used to characterize numerous epitopes from candidate tumor-associated antigens (Tab. 2) . 5 Epitope Deduction Tab. 1. html Tab. 2 Tumor-associated antigens with peptide epitopes identified by the method of deduction Antigen Reference Ig idiotype Telomerase hTERT Survivin Mage-3 P53 Ras Bcr-abl Proteinase-3 Wilm's tumor antigen-1 CEA PSA Her2-neu MUC-1 Folate-binding protein Ep-CAM 26 28 47 48 49 50 51 52 53 54 55 56 57 58 59 candidate epitopes are used to generate specific CTLs that are then evaluated for cytotoxicity against tumor cells expressing the antigen and the appropriate MHC allele.
And van der Bruggen, P. Tcell defined tumor antigens, Curr Opin Immunol 9: 684±93, 1997. , Cerottini, J. , van der Bruggen, P. and Van Pel, A. Tumor antigens recognized by T lymphocytes, Annu Rev Immunol 12: 337±65, 1994. , Tureci, O. and Pfreundschuh, M. Serological identification of human tumor antigens, Curr Opin Immunol 9: 709±16, 1997. 17 Gilboa, E. The makings of a tumor rejection antigen, Immunity 11: 263±70, 1999. 18 Schultze, J. L. and Vonderheide, R. H. From cancer genomics to cancer immunotherapy: toward second-generation tumor antigens, Trends Immunol 22: 516±23, 2001.
Cancer Immune Therapy : Current and Future Strategies by Dr. Gernot Stuhler, Prof. Dr. Peter Walden