By Abdelhamid H. Elgazzar
This ebook, now in its 3rd variation, goals to advertise a deeper realizing of the medical and scientific foundation of nuclear drugs and the recent instructions in scientific imaging. the recent variation has been revised and up to date to mirror fresh alterations and to make sure that the contents are in accordance with most probably destiny instructions. The booklet begins by means of delivering crucial info on basic pathophysiology, mobile constitution and phone biology in addition to the mechanisms of radiopharmaceutical localization in several tissues and cells. The medical purposes of nuclear medication are then offered in a chain of chapters that hide each significant organ approach and relate the elemental wisdom of anatomy, body structure and pathology to the scientific usage of varied scintigraphic modalities. The healing functions of nuclear drugs are mentioned in a separate bankruptcy, and the ultimate bankruptcy is dedicated to the biologic results of ionizing radiations, together with radiation from clinical procedures.
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This e-book, now in its 3rd variation, goals to advertise a deeper figuring out of the medical and medical foundation of nuclear drugs and the hot instructions in clinical imaging. the recent variation has been revised and up-to-date to mirror fresh adjustments and to make sure that the contents are based on most probably destiny instructions.
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Extra resources for The Pathophysiologic Basis of Nuclear Medicine
Elgazzar Fig. 8 Coagulative necrosis in a case of myocardial infarction. Note the necrotic area on the left side (arrow) with no cellular details and loss of nuclei compared to normal myocardial cells on the right side (arrow heads) (Courtesy of Professor Magda Elmonayeri with thanks) necrotic tissue as a result of saponification of free fatty acids with alkali metal ions. The necrotic tissue and the debris usually disappear by a combined process of enzymatic digestion and fragmentation or they become calcified.
Pumps are enzymes using energy from adenosine triphosphate (ATP), light, or other sources of energy to move ions, mainly cations and other solutes across membranes at relatively modest rates, up to concentration gradients as great as 100,000-fold. • Carriers are enzyme-like proteins that provide passive pathways for solutes to move across membranes from a region of higher concentration to lower concentration. Carriers use ion gradients as a source of energy. Some carriers use translocation of an ion down its concentration gradient to drive another ion or solute up a concentration gradient.
The three major classes of membrane lipid molecules are phospholipids (phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, sphingomyelin,), cholesterol, and glycolipids. The lipid composition of different S. Vallabhajosula et al. 2. The proteins of the membrane are responsible for most membrane functions such as transport, cell identity, and cell adhesion and constitute transport channels, transporters, specific receptors, and enzymes. The membrane proteins can be associated with the lipid bilayer in various ways depending on the function of the protein.
The Pathophysiologic Basis of Nuclear Medicine by Abdelhamid H. Elgazzar