By F. Bachmann, Prof. Fedor Bachmann (auth.), Dr. N. Friedel, Prof. Dr. R. Hetzer, Dr. D. Royston (eds.)

ISBN-10: 3662061198

ISBN-13: 9783662061190

ISBN-10: 366206121X

ISBN-13: 9783662061213

Cardiac surgical procedure has constructed dramatically because the first open-he paintings operations have been played within the mid Nineteen Fifties. even though the development of surgical strategy, extracorporeal circulate, and postoperative administration has contributed to a marked relief of morbidity and mortality, the advance of cardiac surgical procedure to its current nation do not have been attainable with no blood substitution by means of homologous donor blood. simply two decades in the past, open-heart operations required a typical of eight devices of blood preserves. The over the top desire of donor blood in these early days was once quite often because of untimely surgical strategy, insecure keep an eye on of anticoagulation, serious blood trauma via extracorporeal stream, and the inability of retransfusion applied sciences that might have allowed the reuse of shed mediastinal blood. The creation of latest applied sciences, resembling normovolemic hemodilution, in­ traoperative autotransfusion, postoperative go back of shed mediastinal blood, and predonation of autologous blood has vastly lowered donor blood requisites. at this time nearly all of regimen coronary artery surgeries may be played with none blood transfusion. Blood loss, despite the fact that, should be huge in sufferers present process advanced valve surgical procedure or reoperations, as they generally require numerous devices of transfused blood. Blood conservation has now turn into a space of significant curiosity for the cardiac general practitioner. This elevated situation is brought on by infectious issues of blood transfusion, specifically hepatitis and, extra lately, AIDS.

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Blood 65 32-40 72. Adelman B, Michelson AD, Greenberg J and Handin RI (1986) Proteolysis ofplatelet glycoprotein Ib by plasmin is facilitated by plasmin lysine-binding regions. Blood 68: 1280-1284 25 73. Stricker RB, Wong D, Shiu DT, Reyes PT and Shuman MA (1986) Activation of plasminogen by tissue plasminogen activator on normal and thrombasthenic platelets: Effects on surface proteins and platelet aggregation. Blood 68: 275-280 74. Takamatsu J, Horne MK and Gralnick HK (1986) Identification of the thrombin receptor on human platelets by chemical crosslinking.

J Bio!. Chem 260: 11107-11114 7. Leung LLK (1984) Role ofthrombospondin in platelet aggregation. J. Clin Invest 74: 17641772 8. Hsu-Lin S-c. Berman CL, Furie BC, August D and Furie B (1984) A platelet membrane protein expressed during platelet activation and secretion. Studies using a monoclonal antibody specific for thrombin-activated platelets. J Bio!. Chem 259: 9121-9126 9. Stenberg PE, McEver RP, Shuman MA, Jacques YV and Bainton DF (1985) A platelet alphagranule membrane protein (GMP-140) is expressed on the plasma membrane after activation.

Surface-bound XIIa cleaves bound prekallikrein to kallikrein, and Factor XI to XIa. Factor XIa is tightly bound to activated HK and slowly dissociates to catalyze Factor IX to IXa [87]. Kallikrein readily dissociates from the surface [87] to accelerate and amplify the contact pathway. Kallikrein reciprocally activates Factor XII, but also cleaves and activates HK, plasminogen [22], prorenin, Cl [26], and it stimulates neutrophils [24, 94]. Activation of the contact system initiates coagulation, activates neutrophils, and pro duces kallikrein, bradykinin, renin and plasmin [25].

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Blood Use in Cardiac Surgery by F. Bachmann, Prof. Fedor Bachmann (auth.), Dr. N. Friedel, Prof. Dr. R. Hetzer, Dr. D. Royston (eds.)

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