By Yuichi Yamamura, Ichiro Azuma (auth.), Thomas Klein, Steven Specter, Herman Friedman, Andor Szentivanyi (eds.)

ISBN-10: 1475714106

ISBN-13: 9781475714104

ISBN-10: 1475714122

ISBN-13: 9781475714128

The subject of organic reaction modifiers has attracted the eye of many biomedical investigators, together with immunologists, oncologists, pharmacologists, microbiologists, and biochemists, in addition to medical practitioners of drugs. This has happened often as a result consciousness that the advanced method of mobile and humoral interactions culminating in a effective immune reaction is lower than beautiful regulatory keep an eye on for regular immune responses and that lack of regulate may well markedly impression the aptitude of a bunch to reply in a effective demeanour to the varied immunologic "insults" encountered within the setting. moreover, organic reaction amendment is taken into account through many to be a ordinary offshoot of the fairly new software of "immunotherapy" to melanoma. it truly is widely known that "immunotherapy" was once practiced on the finish of the final century and the start of this century whilst it was once famous that microbial infections have been as a result of certain species of micro organism and that passive management of serum con­ taining antibody to those microbes or their items may, in lots of situations, favorably effect the result of an infectious process.

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Supernatants were harvested at indicated times and assayed for IF activity. Results are expressed as the mean of four experiments. In all but 2 out of the 24 supernatants assayed, IF activity was in excess of that added at culture initiation. SUMMARY Supernatants of mitogen-induced human PBL cultures contain several lymphokine activities. Analysis of kinetic studies has suggested a correlation in the appearance in culture supernatants of lymphotoxin (LT) and immune interferon (1m-IF). We investigated this interaction between LT and 1m-IF in the serum-free human PBL culture system.

S. Sechar and W. E. Stewart II. 1982. An interim report on studies on the toxic effects of human leukocyte-derived interferon-alpha. J. Interferon Res. 2: 127-130. 16. Merigan, T. C. 17. Petralli, J. , T. C. Merigan and J. R. Wilbur. 1965. Circulating interferon after measles vaccination. New Engl. J. Med. 273: 198-201. 18. Stewart II, W. E. and J. Desmyter. 1975. Molecular heterogeneity of human leukocyte interferon. Virology~: 68-78. 19. , A. Hau, W. Bou, W. E. , S. Nagata and C. Weissmann. 1981.

Leung, N. Stebbing, and D. V. Goeddel. 1981. A single amino acid change in human fibroblast interferon (IFN-Bl) abolishes antiviral activity. Nature 294: 563-565. 11. Week, P. , S. Apperson, E. Hamilton, and N. Stebbing. 1982. Biological properties of genetic hybrids of bacteria-derived human leukocyte interferons. J. Cell. Biochem. Suppl. 6: 104. 12. Week, P. , S. Apperson, N. Stebbing, P. W. Gray, D. Leung, H. M. Shepard, and D. V. Goeddel. 1981. Antiviral activities of hybrids of two major human leukocyte interferons.

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Biological Response Modifiers in Human Oncology and Immunology by Yuichi Yamamura, Ichiro Azuma (auth.), Thomas Klein, Steven Specter, Herman Friedman, Andor Szentivanyi (eds.)


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