By Lodovico Balducci (Editor), Martine Extermann (Editor)
Organic foundation of Geriatric Oncology highlights examine matters which are particular to geriatric oncology within the box of carcinogenesis and melanoma prevention and remedy, in response to the biologic interactions of melanoma and age. It illustrates the advantage of the rules of geriatrics within the administration of melanoma within the older person. This quantity offers a body of reference for practicioners of any specialties enthusiastic about the administration of older sufferers and for oncologists enthusiastic about the administration of melanoma of older participants. it's a resource for easy and medical scientists exploring the interactions and rising info of melanoma and getting older.
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These mice and embryonal fibroblasts derived from them were more resistant to oxidative stress than controls. The spontaneous tumor incidence in the aging cohort of mice was similar to that in wild-type controls. At the molecular level, insulin receptor substrate and the p52 and p66 isoforms of Shc, both main substrates of IGF-1 receptor, showed decreased tyrosine phosphorylation. mediated cellular responses to oxidative stress. Two main pathways the extracellular-signal related kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway and the phosphatidylinositol 3-kinase (PI3K)-Akt pathway – were downregulated in mice.
Mechanisms and Etiology of Tumor Promotion. IARC Scientific Publication No. 56. IARC. Lyon, France. 1984; 497-506 Hanahan D; Weinberg RA: The hallmarks of cancer. Cell 2000;100:57-70 Kaldor JM; Day NE: Interpretation of epidemiological studies in the context of the multistage model of carcinogenesis. ): Mechanisms of Environmental carcinogenesis. Boca Raton. FL. CRC Press. 1987; 2:21-57 Anisimov VN; Zhukovskaya NV; Loktionov AS; et al: Influence of host age on lung colony forming capacity of injected rat rhabdomyosarcoma cells.
The character of these changes could vary in different tissues and might cause uneven tissue aging. Dolle et al. 88 using a lacZ plasmid transgenic mouse model, determined spectra of spontaneous point mutations in different organs in young and old mice. While similar at a young age, the mutation spectra among these organs were significantly different in old age. The authors stressed that the replicative history per se is not the underlying causal factor of age-related organ-specific differences in mutations spectra.
Biological Basis of Geriatric Oncology (Cancer Treatment and Research) by Lodovico Balducci (Editor), Martine Extermann (Editor)