By A. Macieira-Coelho (auth.), Kunio Oota, Masami Iriki, Takashi Makinodan, Lynn S. Baker (eds.)

ISBN-10: 1468437348

ISBN-13: 9781468437348

ISBN-10: 1468437364

ISBN-13: 9781468437362

The challenge of senescence, as mirrored within the background of reli­ gion and philosophy, has lengthy been one of many maximum issues of humankind. against this, gerontology as a department of technology continues to be relatively younger. in past times decade, concomitant with fast growth in our knowing of the fundamental existence sciences, large shops of information approximately organic getting older were gathered. this data, in spite of the fact that, coming up from many clinical disciplines and keen on various degrees of biologic association, turns out virtually random and covers every thing from molecules to human societies. Theories complicated to interpret the evidence and to appreciate the mech­ anisms considering senescence have remained in person, instead of normal, territories. It has lengthy been felt by means of a few gerontologists that it used to be time for a few of the experts to step again and take a generalist view of gerontology, to re-examine and reevaluate the culmination in their analyt­ ical goals at various degrees inside a broader context. a few others might imagine it nonetheless untimely. It appeared, notwithstanding, that almost all of these who accrued in Tokyo at the social gathering of the XIth foreign Congress of Gerontology have been of the opinion that there has been a lot to be received in trying to find interrelationships one of the proof and theories originated within the diverse degrees of investiga­ tion in an try and realize and delight in the organic drama of senescence as an entity.

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Schaeffer, A diploid rat liver cell culture. I. Characterization and sensitivity to alfatoxin B1, In Vitro 9:286 (1914). 18. H. Masuji, H. Nakabayashi, and J. Sato, Long-term cultivation of two diploid epithelial cell lines derived from normal rat liver cells, Acta Med. Okayama 28:281 (1914). MECHANISM OF AGE-DEPENDENT DECREASE IN SULFATION OF CHONDROITIN SULFATE Sei-itsu Murota·, Atsushi Honda·'··, Midori Abe·, and Yo Mori·· ·Department of Pharmacology, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo 173 and ··Department of Biochemistry, Tokyo College of Pharmacy, Hachioji-shi, Tokyo 192-03, Japan INTRODUCTION A number of investigators have been concerned with the relationship between extracellular substances and aging (1,2).

23 Y. Mitsui and E. L. ~. Cell Re~. 103:23, 1976. 9 J. J. Wolosewick and R. K. Porter, Observations on the morphological heterogeneity of WI-38, ~. J. Anat. 149:191, 1911. 10. L. N. Kapp and R. R. Klevecz, The cell cycle of low passage and high passage human diploid fibroblasts, EXE' Cell Res. 101:154, 1916. 11. Y. Mitsui, S. Aizawa, and K. Matsuoka, The relation of cell nuclei and surface membranes to the capacity of cell proliferation in human diploid fibroblasts, in:"Proceedings of XIth International Congress of Gerontology;" Excepta Medica, The Netherlands, p.

ABE, AND Y. :a ~-----------. (b) DIDI 10 10 0 C'I E ....... '"0 I M X til '" E M Q. U 8 z ..... 0 ~ 0 ::I: ....... ;;: "" 5 5 0- ""u 0 z ..... 0 I t.......... -~ 15 3 MONTHS Fig. 2. 0 15 3 MONTHS Effect of age on incorporation of 3H-glucosamine and 35S- su lfate into glycosaminoglycan. The cartilage slices were incubated in Ham's F-12 medium containing 5 ~Ci of 3H-glucosamine and 5 ~Ci of 35S-sulfuric acid for 3 hr, and the doubly labeled glycosaminoglycan formed was used for subsequent analyses.

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Aging Phenomena: Relationships among Different Levels of Organization by A. Macieira-Coelho (auth.), Kunio Oota, Masami Iriki, Takashi Makinodan, Lynn S. Baker (eds.)


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