By S. González-Moreno
Malignant peritoneal sickness in its a number of types is a devastating for sufferers who are suffering from it and it poses an important problem for the clinicians caring for them. study efforts during this box have commonly been scarce below the belief of a uniformly deadly and hopeless outcome.
In the previous couple of a long time a renewed curiosity in peritoneal carcinomatosis and first peritoneal malignancies has happened. exceptional beneficial effects said with the employment of competitive cytoreductive surgical procedure mixed with perioperative intraperitoneal chemotherapy have catalysed a metamorphosis within the notion and therapy choices for those illnesses. chosen sufferers can now be provided a curative-intent blend remedy, while long ago purely the very best palliation will be considered.
This publication is a accomplished compilation of the recent wisdom in peritoneal floor oncology within the sunrise of the twenty-first century. It covers the full spectrum of the newest study conducted in peritoneal malignant dissemination, from its pathogenesis and molecular mechanisms to the most recent scientific trials. also, the necessities of perioperative intraperitoneal chemotherapy and the fashionable histopathological evaluate of peritoneal floor malignancy are reviewed. a special historic standpoint on how this new wisdom has opened up through the years is helping indicate the longer term learn instructions to be pursued. top specialists during this box from around the globe, together with the pioneers who gave start to this new period in oncology, shape an unbeatable and striking panel of authors.
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Extra info for Advances in Peritoneal Surface Oncology (Recent Results in Cancer Research)
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Kawamura et al. reported that a highly metastatic cell line on the peritoneum overexpresses integrin α1, α2, and β1 . Furthermore, neutralizing antibody for integrin α1, α2, and β1 subunits can inhibit the adhesion of cancer cells to the peritoneum. These results suggest integrins as target molecules to consider in research for the prevention of peritoneal dissemination. Furthermore, complementary DNA microarray and histochemical analyses revealed differences in the concerted expressions of several genes coding for matrix proteinases, cell adhesion, motility, angiogenesis, and proliferation between the highly metastatic and parental cell lines .
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Advances in Peritoneal Surface Oncology (Recent Results in Cancer Research) by S. González-Moreno