By S. González-Moreno

ISBN-10: 3540307591

ISBN-13: 9783540307594

Malignant peritoneal sickness in its a number of types is a devastating for sufferers who are suffering from it and it poses an important problem for the clinicians caring for them. study efforts during this box have commonly been scarce below the belief of a uniformly deadly and hopeless outcome.

In the previous couple of a long time a renewed curiosity in peritoneal carcinomatosis and first peritoneal malignancies has happened. exceptional beneficial effects said with the employment of competitive cytoreductive surgical procedure mixed with perioperative intraperitoneal chemotherapy have catalysed a metamorphosis within the notion and therapy choices for those illnesses. chosen sufferers can now be provided a curative-intent blend remedy, while long ago purely the very best palliation will be considered.

This publication is a accomplished compilation of the recent wisdom in peritoneal floor oncology within the sunrise of the twenty-first century. It covers the full spectrum of the newest study conducted in peritoneal malignant dissemination, from its pathogenesis and molecular mechanisms to the most recent scientific trials. also, the necessities of perioperative intraperitoneal chemotherapy and the fashionable histopathological evaluate of peritoneal floor malignancy are reviewed. a special historic standpoint on how this new wisdom has opened up through the years is helping indicate the longer term learn instructions to be pursued. top specialists during this box from around the globe, together with the pioneers who gave start to this new period in oncology, shape an unbeatable and striking panel of authors.

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Extra info for Advances in Peritoneal Surface Oncology (Recent Results in Cancer Research)

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Dissemination of gastric cancer and its potential as a novel marker for the detection of peritoneal micrometastases with real-time RT-PCR. Br J Cancer 90:665– 671 29. Bando E, Yonemura Y, Takeshita Y et al. (1999) Intraoperative lavage for cytological examination in 1, 297 patients with gastric carcinoma. Am J Surg 178:256– 262 30. Wu CC, Chen JT, Chang MC et al. (1997) Optimal surgical strategy for potentially curable serosa-involved gastric carcinoma with intraperitoneal free cancer cells. J Am Coll Surg 184:611–617 31.

Kawamura et al. reported that a highly metastatic cell line on the peritoneum overexpresses integrin α1, α2, and β1 [11]. Furthermore, neutralizing antibody for integrin α1, α2, and β1 subunits can inhibit the adhesion of cancer cells to the peritoneum. These results suggest integrins as target molecules to consider in research for the prevention of peritoneal dissemination. Furthermore, complementary DNA microarray and histochemical analyses revealed differences in the concerted expressions of several genes coding for matrix proteinases, cell adhesion, motility, angiogenesis, and proliferation between the highly metastatic and parental cell lines [27].

Quan SH (1959) Cul-de-sac smears for cancer cells. Surgery 45:258–263 19. Skipper D, Cooper AJ, Marston JE, Taylor I (1987). Exfoliated cells and in vitro growth in colorectal cancer. Br J Surg 74:1049–1052 3 Pathological Evaluation and Implications of Serosal Involvement in Gastrointestinal Cancer 20. Ambrose NS, MacDonald F, Young J, Thompson H, Keighley MR (1989) Monoclonal antibody and cytological detection of free malignant cells in the peritoneal cavity during resection of colorectal cancer–can monoclonal antibodies do better?

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Advances in Peritoneal Surface Oncology (Recent Results in Cancer Research) by S. González-Moreno


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