By Kendra L. Cann, Sui Huang, Graham Dellaire (auth.), Niall M. Adams, Paul S. Freemont (eds.)

ISBN-10: 9048198984

ISBN-13: 9789048198986

ISBN-10: 9048198992

ISBN-13: 9789048198993

This publication offers a photo of the state-of-the paintings within the examine of mammalian mobilephone nuclear structure, and lines a various variety of chapters written by means of most sensible researchers. A key element is an emphasis on specific and repeatable quantitative research and simulation as well as the extra widespread organic point of view. The fusion of such fabric frames the way forward for the self-discipline. Quantitative contributions tension reproducible and powerful 3D research, utilizing numerous instruments starting from aspect development research to form registration equipment. organic insights contain the function of nuclear subdomains in melanoma, nuclear molecular vehicles, and a holistic view of gene transcription.

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1). 1 The PNC Formation is Associated with Malignant Phenotype In Vitro and In Vivo Earlier studies showed that PNC prevalence (the percentage of cells containing at least one PNC) is significantly increased in cancer cell lines in vitro (Huang et al. 1997). A more recent survey of a large number of normal and malignant cells either transformed in vitro or isolated from human tumours further supports the association of PNCs with cancer cells (Norton et al. 2008a). PNCs are absent in normal primary cells including mouse and human embryonic stem cells and are rare in immortalized cells.

2009). This silver staining technique relies on the argyrophilic nature of several nucleolar proteins, specifically the rRNA processing factors nucleophosmin (NPM, B23) and nucleolin, the basal transcription factor UBF, and the largest subunit of RNA polymerase I (Roussel and Hernandez-Verdun 1994). The resulting silver-stained structures are termed the AgNORs, and are visible both in interphase (Maggi and Weber 2005), and at the sites of the rDNA genes in mitosis (Heliot et al. 2000). In interphase, the area of AgNOR staining is related to both nucleolar size and RNA polymerase I activity (Derenzini et al.

2009b), providing additional explanations for why it is expressed in stem and cancer cells, and why depletion would induce a p53-dependent arrest. L. Cann et al. 3 Nucleophosmin Like nucleostemin, NPM is also implicated in cancer development, especially ­haematological malignancies. For example, approximately 35% of adult acute myeloid leukemia patients have mutations in NPM that cause it to be relocalized to the cytoplasm, and these mutations are thought to be tumour-initiating (Gjerset 2006).

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Advances in Nuclear Architecture by Kendra L. Cann, Sui Huang, Graham Dellaire (auth.), Niall M. Adams, Paul S. Freemont (eds.)


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